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Article

Srs2 removes deadly recombination intermediates independently of its interaction with SUMO-modified PCNA.

Nucleic acids research - 1 Sept 2008

Le Breton Cyrille, Dupaigne Pauline, Robert Thomas, Le Cam Eric, Gangloff Serge, Fabre Francis, Veaute Xavier

Abstract excerpt

Saccharomyces cerevisiae Srs2 helicase plays at least two distinct functions. One is to prevent recombinational repair through its recruitment by sumoylated Proliferating Cell Nuclear Antigen (PCNA), evidenced in postreplication-repair deficient cells, and a second one is to eliminate potentially lethal intermediates formed by recombination proteins. Both actions are believed to involve the capacity of Srs2 to...

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Source

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Identifiers

PMID: 18658248
DOI: 10.1093/nar/gkn441
PMCID: PMC2528196

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Srs2 removes deadly recombination intermediates independently of its interaction with SUMO-modified PCNA.PMID 18658248Read ↗

SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase.Semantic proximity Read ↗

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Srs2 and Mus81-Mms4 Prevent Accumulation of Toxic Inter-Homolog Recombination Intermediates.Semantic proximity Read ↗

The human F-Box DNA helicase FBH1 faces Saccharomyces cerevisiae Srs2 and postreplication repair pathway roles.Semantic proximity Read ↗

Access to PCNA by Srs2 and Elg1 Controls the Choice between Alternative Repair Pathways in Saccharomyces cerevisiae.Semantic proximity Read ↗

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