Article
Postreplication repair and PCNA modification in Schizosaccharomyces pombe.
Molecular biology of the cell - 1 Jul 2006
Frampton Jonathan, Irmisch Anja, Green Catherine M, Neiss Andrea, Trickey Michelle, Ulrich Helle D, Furuya Kanji, Watts Felicity Z, Carr Antony M, Lehmann Alan R
Abstract excerpt
Ubiquitination of proliferating cell nuclear antigen (PCNA) plays a crucial role in regulating replication past DNA damage in eukaryotes, but the detailed mechanisms appear to vary in different organisms. We have examined the modification of PCNA in Schizosaccharomyces pombe. We find that, in response to UV irradiation, PCNA is mono- and poly-ubiquitinated in a manner similar to that in Saccharomyces cerevisiae....
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