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Article

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

Nature - 12 Sept 2002

Hoege Carsten, Pfander Boris, Moldovan George-Lucian, Pyrowolakis George, Jentsch Stefan

Abstract excerpt

The RAD6 pathway is central to post-replicative DNA repair in eukaryotic cells; however, the machinery and its regulation remain poorly understood. Two principal elements of this pathway are the ubiquitin-conjugating enzymes RAD6 and the MMS2-UBC13 heterodimer, which are recruited to chromatin by the RING-finger proteins RAD18 and RAD5, respectively. Here we show that UBC9, a small ubiquitin-related modifier...

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Source

Identifiers

PMID: 12226657
DOI: 10.1038/nature00991

Genes

PCNA
RAD18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.PMID 12226657Read ↗

Role of SUMO modification of human PCNA at stalled replication fork.Semantic proximity Read ↗

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PCNA Modifications for Regulation of Post-Replication Repair PathwaysSemantic proximity Read ↗

E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6.Semantic proximity Read ↗

SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase.Semantic proximity Read ↗

Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitinationSemantic proximity Read ↗

Human SHPRH is a ubiquitin ligase for Mms2–Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigenSemantic proximity Read ↗

Ubiquitin binding site of the ubiquitin E2 variant (UEV) protein Mms2 is required for DNA damage tolerance in the yeast RAD6 pathway.Semantic proximity Read ↗

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Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forksSemantic proximity Read ↗

Activation of the SUMO modification system is required for the accumulation of RAD51 at sites containing DNA damageSemantic proximity Read ↗

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