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Article

Axin2 regulates chondrocyte maturation and axial skeletal development.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Jan 2010

Dao Debbie Y, Yang Xue, Flick Lisa M, Chen Di, Hilton Matthew J, O'Keefe Regis J

Abstract excerpt

Axis inhibition proteins 1 and 2 (Axin1 and Axin2) are scaffolding proteins that modulate at least two signaling pathways that are crucial in skeletogenesis: the Wnt/beta-catenin and TGF-beta signaling pathways. To determine whether Axin2 is important in skeletogenesis, we examined the skeletal phenotype of Axin2-null mice in a wild-type or Axin1(+/-) background. Animals with disrupted Axin2 expression displayed...

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Identifiers

PMID: 19623616
DOI: 10.1002/jor.20954
PMCID: PMC2853598

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Axin2 regulates chondrocyte maturation and axial skeletal development.PMID 19623616Read ↗

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