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Article

The role of Axin2 in calvarial morphogenesis and craniosynostosis.

Development (Cambridge, England) - 1 Apr 2005

Yu Hsiao-Man Ivy, Jerchow Boris, Sheu Tzong-Jen, Liu Bo, Costantini Frank, Puzas J Edward, Birchmeier Walter, Hsu Wei

Abstract excerpt

Axin1 and its homolog Axin2/conductin/Axil are negative regulators of the canonical Wnt pathway that suppress signal transduction by promoting degradation of beta-catenin. Mice with deletion of Axin1 exhibit defects in axis determination and brain patterning during early embryonic development. We show that Axin2 is expressed in the osteogenic fronts and periosteum of developing sutures during skull morphogenesis....

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Source

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Identifiers

PMID: 15790973
DOI: 10.1242/dev.01786
PMCID: PMC1828115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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