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Article

The links between axin and carcinogenesis

25 Feb 2005

Abstract excerpt

The products of the two mammalian Axin genes (Axin1 and its homologue Axin2) are essential for the degradation of beta catenin, a component of Wnt signalling that is frequently dysregulated in cancer cells. Axin is a multidomain scaffold protein that has many functions in biological signalling pathways. Overexpression of mutant [corrected] axin results in axis duplication in mouse embryos. Wnt signalling activity...

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Identifiers

PMID: 15735151
DOI: 10.1136/jcp.2003.009506

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