Article
Diversity of axin in signaling pathways and its relation to colorectal cancer.
Medical oncology (Northwood, London, England) - 1 Dec 2011
Parveen Nighat, Hussain Mahboob Ul, Pandith Arshad A, Mudassar Syed
Abstract excerpt
Colorectal cancer is one of the commonest cancers in western world, while majority of cases of CRC are sporadic, a significant minority occurs as a result of inherited genetic mutations. Various studies have demonstrated that tumorigenesis of colon arises as a result of accumulation of multiple genetic alterations targeting the single signal transduction pathway. Genetic alteration of axin has been implicated in...
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