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Article

Axin1‘s mystique in manipulating microbiome amidst colitis

27 Nov 2023

Abstract excerpt

Classically, Axin1 is considered a regulator of Wnt/β-catenin signaling.However, Axin1's roles in host-microbial interactions have been unknown.Our recent study has demonstrated that deletion of intestinal epithelial Axin1 in epithelial cells and Paneth cells protects the host against colitis by enhancing Akkermansia muciniphila.Loss of intestinal epithelial or Paneth cell Axin1 results in increased Wnt/β-catenin...

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Identifiers

PMID: 38010886
DOI: 10.1080/19490976.2023.2286674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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