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Article

AXIN1 and AXIN2 variants in gastrointestinal cancers.

Cancer letters - 1 Dec 2014

Mazzoni Serina M, Fearon Eric R

Abstract excerpt

Mutations in the APC (adenomatous polyposis coli) gene, which encodes a multi-functional protein with a well-defined role in the canonical Wnt pathway, underlie familial adenomatous polypsosis, a rare, inherited form of colorectal cancer (CRC) and contribute to the majority of sporadic CRCs. However, not all sporadic and familial CRCs can be explained by mutations in APC or other genes with well-established roles...

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Share to Amino Acid Sequence
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Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25236910
DOI: 10.1016/j.canlet.2014.09.018
PMCID: PMC4298141

Genes

AXIN1
AXIN2
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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AXIN1 and AXIN2 variants in gastrointestinal cancers.PMID 25236910Read ↗

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The links between axin and carcinogenesisSemantic proximity Read ↗

Variations in AXIN2 predict risk and prognosis of colorectal cancerSemantic proximity Read ↗

Hereditary Colorectal Cancer and Polyposis Syndromes Caused by Variants in Uncommon Genes.Semantic proximity Read ↗

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Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia.Semantic proximity Read ↗

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