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Article

A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity.

Human molecular genetics - 1 Jul 2005

Yuan Hsiang-Yu, Chen Jin-Jer, Lee M T Michael, Wung Ju-Chieh, Chen Ying-Fu, Charng Min-Ji, Lu Ming-Jen, Hung Chi-Ren, Wei Chun-Yu, Chen Chien-Hsiun, Wu Jer-Yuarn, Chen Yuan-Tsong

Abstract excerpt

Warfarin, a commonly prescribed anticoagulant, exhibited large inter-individual and inter-ethnic differences in the dose required for its anticoagulation effect. Asian populations, including Chinese, require a much lower maintenance dose than Caucasians, for which the mechanisms still remain unknown. We determined DNA sequence variants in CYP2C9 and VKORC1 in 16 Chinese patients having warfarin sensitivity (< or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15888487
DOI: 10.1093/hmg/ddi180

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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