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Article

Responsiveness to low-dose warfarin associated with genetic variants of VKORC1, CYP2C9, CYP2C19, and CYP4F2 in an Indonesian population.

European journal of clinical pharmacology - 1 Mar 2013

Rusdiana T, Araki T, Nakamura T, Subarnas A, Yamamoto K

Abstract excerpt

PURPOSE: The aim of this study was to assess the pharmacokinetics and pharmacodynamics of warfarin associated with genetic polymorphisms in VKORC1, CYP2C9, CYP2C19, and CYP4F2 in Indonesian patients treated with low-dose warfarin. METHODS: Genotyping of VKORC1, CYP2C9, CYP2C19, and CYP4F2 was carried out in 103 patients treated with a daily dose of 1-2 mg warfarin, 89 of whom were treated with a fixed daily dose...

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Identifiers

PMID: 22855348
DOI: 10.1007/s00228-012-1356-9

Genes

VKORC1

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