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Article

Pharmacokinetic and pharmacodynamic variation associated with VKORC1 and CYP2C9 polymorphisms in Thai patients taking warfarin.

Drug metabolism and pharmacokinetics - 1 Jan 2010

Sangviroon Alisara, Panomvana Duangchit, Tassaneeyakul Wichittra, Namchaisiri Jule

Abstract excerpt

We investigated the influence of genetic polymorphisms of CYP2C9 and VKORC1 genotypes on the pharmacokinetics and pharmacodynamics of warfarin and established an equation for predicting the maintenance dose of warfarin in the Thai population using genetic and non-genetic factors. The CYP2C9*2, CYP2C9*3, VKORC1 C1173T and VKORC1 G-1639A genotypes were detected by realtime PCR using fluorogenic hybridization...

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Source

Identifiers

PMID: 20930419
DOI: 10.2133/dmpk.dmpk-10-rg-059

Genes

VKORC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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