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Article

Warfarin dosage response related pharmacogenetics in Chinese population.

PloS one - 1 Jan 2015

Li Siyue, Zou Yuangao, Wang Xia, Huang Xunbei, Sun Yong, Wang Yuqing, Dong Li, Jiang Hong

Abstract excerpt

OBJECTIVES: As the most frequently prescribed anticoagulant, warfarin has large inter-individual variability in dosage. Genetic polymorphisms could largely explain the differences in dosage requirement. rs9923231 (VKORC1), rs7294 (VKORC1), rs1057910 (CYP2C9), rs2108622 (CYP4F2), and rs699664 (GGCX) involved in the warfarin action mechanism and the circulatory vitamin K were selected to investigate their...

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Share to Algorithms
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Share to Dose-Response Relationship, Drug
Share to Genetic Variation
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Share to Polymorphism, Genetic
Share to Vitamin K Epoxide Reductases
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Source

Open in PubMed Open full text

Identifiers

PMID: 25594941
DOI: 10.1371/journal.pone.0116463
PMCID: PMC4296935

Genes

VKORC1
GGCX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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