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Association between CYP2C9 and VKORC1 genetic polymorphisms and efficacy and safety of warfarin in Chinese patients.

Pharmacogenetics and genomics - 1 Jun 2024

Zhang Suli, Zhao Mingzhe, Zhong Shilong, Niu Jiamin, Zhou Lijuan, Zhu Bin, Su Haili, Cao Wei, Xing Qinghe, Yan Hongli, Han Xia, Fu Qihua, Li Qiang, Chen Luan, Yang Fan, Zhang Na, Wu Hao, He Lin, Qin Shengying

Abstract excerpt

OBJECTIVES: Genetic variation has been a major contributor to interindividual variability of warfarin dosage requirement. The specific genetic factors contributing to warfarin bleeding complications are largely unknown, particularly in Chinese patients. In this study, 896 Chinese patients were enrolled to explore the effect of CYP2C9 and VKORC1 genetic variations on both the efficacy and safety of warfarin...

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Source

Identifiers

PMID: 38470454
DOI: 10.1097/FPC.0000000000000526

Genes

CYP2C9
VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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