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Article

VKORC1 gene variations are the major contributors of variation in warfarin dose in Japanese patients.

Clinical pharmacology and therapeutics - 1 Aug 2006

Obayashi Kyoko, Nakamura Katsunori, Kawana Junichi, Ogata Hiroyasu, Hanada Kazuhiko, Kurabayashi Masahiko, Hasegawa Akira, Yamamoto Koujirou, Horiuchi Ryuya

Abstract excerpt

OBJECTIVES: To compare the genetic and clinical factors that cause large interpatient variability and ethnic differences in warfarin efficacy, we investigated variations of the VKORC1, CYP2C9, and CYP2C19 genes in Japanese subjects. Furthermore, we evaluated the genetic variations and clinical data as contributors of variation in warfarin maintenance dose. METHODS: Gene variations of VKORC1, CYP2C9, and CYP2C19...

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Source

Identifiers

PMID: 16890578
DOI: 10.1016/j.clpt.2006.04.010

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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