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Article

Analysis of reciprocal congenic lines reveals the C3H/HeJ genome to be highly resistant to ApcMin intestinal tumorigenesis.

Genomics - 1 Nov 2004

Koratkar Revati, Silverman Karen A, Pequignot Ed, Hauck Walter W, Buchberg Arthur M, Siracusa Linda D

Abstract excerpt

Genetic background affects polyp development in the Multiple intestinal neoplasia (Apc(Min)) mouse model. The Modifier of Min 1 (Mom1) locus accounts for approximately 50% of the variation in polyp multiplicity. We generated reciprocal congenic lines, such that the recipient C57BL/6J (B6) strain carries a donor C3H/HeJ (C3H) Mom1 allele, and the recipient C3H strain carries a donor B6 Mom1 allele. Hybrid progeny...

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Share to Adenomatous Polyposis Coli
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Mammalian

Share to Genes, APC

Share to Intestinal Polyps

Share to Mice, Congenic

Share to Mice, Inbred C3H

Share to Phospholipases A

Source

Identifiers

PMID: 15475263
DOI: 10.1016/j.ygeno.2004.07.010

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Analysis of reciprocal congenic lines reveals the C3H/HeJ genome to be highly resistant to ApcMin intestinal tumorigenesis.PMID 15475263Read ↗

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