Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct pathways of genomic progression to benign and malignant tumors of the liver.

Proceedings of the National Academy of Sciences of the United States of America - 11 Sept 2007

Tward Aaron D, Jones Kirk D, Yant Stephen, Cheung Siu Tim, Fan Sheung Tat, Chen Xin, Kay Mark A, Wang Rong, Bishop J Michael

Abstract excerpt

We used several of the genetic lesions commonly associated with human liver tumors to reconstruct genetic progression to hepatocellular carcinoma and adenoma in mouse models. We initiated tumorigenesis with a transgene of the protooncogene MET or by hydrodynamic transfection of MET in combination with other genes into the livers of adult animals. Hepatocellular carcinoma in both instances arose from cooperation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma, Liver Cell
Share to beta Catenin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular

Share to Hepatocyte Nuclear Factor 1-alpha

Share to Liver Neoplasms, Experimental

Share to Precipitin Tests

Share to Proto-Oncogene Proteins c-met

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 17785413
DOI: 10.1073/pnas.0706578104
PMCID: PMC1964540

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct pathways of genomic progression to benign and malignant tumors of the liver.PMID 17785413Read ↗

Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point‐mutant β‐cateninSemantic proximity Read ↗

Genomic progression in mouse models for liver tumors.Semantic proximity Read ↗

Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice.Semantic proximity Read ↗

Targeting β‐catenin in hepatocellular cancers induced by coexpression of mutant β‐catenin and K‐Ras in miceSemantic proximity Read ↗

Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-alpha.Semantic proximity Read ↗

Molecular Mechanisms of Hepatocarcinogenesis in Transgenic Mouse Models of Liver CancerSemantic proximity Read ↗

Molecular pathogenesis of hepatic adenomas and its implications for surgical management.Semantic proximity Read ↗

Oncogenic potential of N-terminal deletion and S45Y mutant β-catenin in promoting hepatocellular carcinoma development in miceSemantic proximity Read ↗

Oncogenic Determination of a Broad Spectrum of Phenotypes of Hepatocyte-Derived Mouse Liver Tumors.Semantic proximity Read ↗

<i>DNAJB1</i> - <i>PRKACA</i> fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinomaSemantic proximity Read ↗

Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice.Semantic proximity Read ↗

Cooperation between MYC and β-catenin in liver tumorigenesis requires Yap/TazSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.