Article
Action of Min and Mom1 on neoplasia in ectopic intestinal grafts.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Oct 1996
Gould K A, Dove W F
Abstract excerpt
Mice heterozygous for Min, a mutant allele of Apc, develop adenomas throughout the intestinal tract. Tumor multiplicity in Min mice is influenced by genetic modifier loci. Previously, we mapped one of these modifier loci, Mom1, to distal mouse chromosome 4. Mom1 is a semidominant modifier of both...
Topics
- Adenomatous Polyposis Coli Protein
- Animals
- Cytoskeletal Proteins
- Gene Expression Regulation, Neoplastic
- Genes, APC
- Intestinal Neoplasms
- Intestines
- Mice
- Mutation
- Transplantation, Isogeneic