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Article

Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis.

Nature genetics - 1 Sept 1997

Cormier R T, Hong K H, Halberg R B, Hawkins T L, Richardson P, Mulherkar R, Dove W F, Lander E S

Abstract excerpt

Individuals inheriting the same mutation predisposing to cancer may show very different outcomes, ranging from early aggressive cancer to disease-free survival. Experimental mouse models can provide a powerful tool to identify factors in the environment and genetic background that account for such modifications. The Min mouse strain, in which the ApcMin mutation disrupts the mouse homologue of the human familial...

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PMID: 9288104
DOI: 10.1038/ng0997-88

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis.PMID 9288104Read ↗

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia.Semantic proximity Read ↗

Localized gene action controlling intestinal neoplasia in mice.Semantic proximity Read ↗

Variants at the secretory phospholipase A2 (PLA2G2A) locus: analysis of associations with familial adenomatous polyposis and sporadic colorectal tumours.Semantic proximity Read ↗

Action of Min and Mom1 on neoplasia in ectopic intestinal grafts.Semantic proximity Read ↗

Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice.Semantic proximity Read ↗

A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36.Semantic proximity Read ↗

Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice.Semantic proximity Read ↗

Three secretory phospholipase A(2) genes that map to human chromosome 1P35-36 are not mutated in individuals with attenuated adenomatous polyposis coli.Semantic proximity Read ↗

Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.Semantic proximity Read ↗

Genetic mapping of novel modifiers for ApcMin induced intestinal polyps’ development using the genetic architecture power of the collaborative cross miceSemantic proximity Read ↗

The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression.Semantic proximity Read ↗

Pla2g2a Attenuates Colon Tumorigenesis in Azoxymethane-Treated C57BL/6 Mice; Expression Studies Reveal Pla2g2a Target Genes and PathwaysSemantic proximity Read ↗

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