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Article

PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis.

The Journal of experimental medicine - 2 May 2005

Dakic Aleksandar, Metcalf Donald, Di Rago Ladina, Mifsud Sandra, Wu Li, Nutt Stephen L

Abstract excerpt

Although the transcription factor PU.1 is essential for fetal lymphomyelopoiesis, we unexpectedly found that elimination of the gene in adult mice allowed disturbed hematopoiesis, dominated by granulocyte production. Impaired production of lymphocytes was evident in PU.1-deficient bone marrow (BM), but myelocytes and clonogenic granulocytic progenitors that are responsive to granulocyte colony-stimulating factor...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15867096
DOI: 10.1084/jem.20050075
PMCID: PMC2213186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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