Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

doi:10.1126/science.8079170

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Article

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

Science (New York, N.Y.) - 9 Sept 1994

Scott E W, Simon M C, Anastasi J, Singh H

Abstract excerpt

The transcription factor PU.1 is a hematopoietic-specific member of the ets family. Mice carrying a mutation in the PU.1 locus were generated by gene targeting. Homozygous mutant embryos died at a late gestational stage. Mutant embryos produced normal numbers of megakaryocytes and erythroid proge...

Topics

Animals
DNA-Binding Proteins
Erythropoiesis
Female
Gene Rearrangement
Hematopoiesis
Hematopoietic Stem Cells
Lymphocytes
Macrophages
Male
Mice
Mice, Inbred C57BL
Monocytes
Mutation
Neutrophils
Retroviridae Proteins, Oncogenic
Transcription Factors

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