Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

Science (New York, N.Y.) - 9 Sept 1994

Scott E W, Simon M C, Anastasi J, Singh H

Abstract excerpt

The transcription factor PU.1 is a hematopoietic-specific member of the ets family. Mice carrying a mutation in the PU.1 locus were generated by gene targeting. Homozygous mutant embryos died at a late gestational stage. Mutant embryos produced normal numbers of megakaryocytes and erythroid progenitors, but some showed an impairment of erythroblast maturation. An invariant consequence of the mutation was a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to Gene Rearrangement
Share to Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Macrophages

Share to Mice, Inbred C57BL

Share to Mutation

Share to Transcription Factors

Source

Identifiers

PMID: 8079170
DOI: 10.1126/science.8079170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.PMID 8079170Read ↗

Surprising new roles for PU.1 in the adaptive immune response.Semantic proximity Read ↗

Analysis of concentration-dependent functions of PU.1 in hematopoiesis using mouse models.Semantic proximity Read ↗

PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors.Semantic proximity Read ↗

PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis.Semantic proximity Read ↗

Myeloid development is selectively disrupted in PU.1 null mice.Semantic proximity Read ↗

PU.1, a shared transcriptional regulator of lymphoid and myeloid cell fates.Semantic proximity Read ↗

Reduction in PU.1 activity results in a block to B-cell development, abnormal myeloid proliferation, and neonatal lethality.Semantic proximity Read ↗

PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors.Semantic proximity Read ↗

Regulation of B lymphocyte and macrophage development by graded expression of PU.1.Semantic proximity Read ↗

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.Semantic proximity Read ↗

Potential autoregulation of transcription factor PU.1 by an upstream regulatory element.Semantic proximity Read ↗

Mouse models in the study of the Ets family of transcription factors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.