Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of concentration-dependent functions of PU.1 in hematopoiesis using mouse models.

Blood cells, molecules & diseases - 1 Jan 2000

DeKoter Rodney P, Kamath Meghana B, Houston Isaac B

Abstract excerpt

The Ets family transcription factor PU.1, encoded by the gene Sfpi1, is essential for normal hematopoiesis. A number of studies have suggested that changes in PU.1 concentration play a role in directing cell fate decisions during hematopoiesis. However, the stages of hematopoietic development at which changes in PU.1 concentration are important have not been defined until recently. Experiments using conditional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Hematopoiesis
Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 17629523
DOI: 10.1016/j.bcmd.2007.06.004
PMCID: PMC2040501

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of concentration-dependent functions of PU.1 in hematopoiesis using mouse models.PMID 17629523Read ↗

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.Semantic proximity Read ↗

Reduction in PU.1 activity results in a block to B-cell development, abnormal myeloid proliferation, and neonatal lethality.Semantic proximity Read ↗

Surprising new roles for PU.1 in the adaptive immune response.Semantic proximity Read ↗

Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.Semantic proximity Read ↗

Myeloid development is selectively disrupted in PU.1 null mice.Semantic proximity Read ↗

PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors.Semantic proximity Read ↗

PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis.Semantic proximity Read ↗

Regulation of B lymphocyte and macrophage development by graded expression of PU.1.Semantic proximity Read ↗

The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.Semantic proximity Read ↗

Mouse models in the study of the Ets family of transcription factors.Semantic proximity Read ↗

Potential autoregulation of transcription factor PU.1 by an upstream regulatory element.Semantic proximity Read ↗

PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AMLSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.