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Article

Surprising new roles for PU.1 in the adaptive immune response.

Immunological reviews - 1 Nov 2010

Carotta Sebastian, Wu Li, Nutt Stephen L

Abstract excerpt

The ETS family transcription factor PU.1 is one of the best-studied regulators of hematopoiesis. While research over the past two decades has established that PU.1 is essential for many aspects of lymphoid and myeloid cell development, the more recent development of the tools that enable PU.1 function to be assessed in adult mice and in specific cell lineages has led to the discovery of some surprising new roles...

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Identifiers

PMID: 20969585
DOI: 10.1111/j.1600-065X.2010.00955.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Surprising new roles for PU.1 in the adaptive immune response.PMID 20969585Read ↗

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.Semantic proximity Read ↗

PU.1, a shared transcriptional regulator of lymphoid and myeloid cell fates.Semantic proximity Read ↗

Analysis of concentration-dependent functions of PU.1 in hematopoiesis using mouse models.Semantic proximity Read ↗

The role of a key transcription factor PU.1 in autoimmune diseasesSemantic proximity Read ↗

PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors.Semantic proximity Read ↗

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PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors.Semantic proximity Read ↗

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Mouse models in the study of the Ets family of transcription factors.Semantic proximity Read ↗

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