Article

PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

2020-05-20

Abstract excerpt

<h4>Summary</h4> Loss of hematopoietic stem cell (HSC) quiescence and resulting clonal expansion are common initiating events in the development of hematological malignancy. Likewise, chronic inflammation related to aging, disease and/or tissue damage is associated with leukemia progression, though its role in oncogenesis is not clearly defined. Here, we show that PU.1-dependent repression of protein synthesis an...

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Literature Corpus work: d490a21c-53c0-513f-a876-a41b8e547934
DOI: 10.1101/2020.05.18.102830

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