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Article

PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors.

The EMBO journal - 3 Aug 1998

DeKoter R P, Walsh J C, Singh H

Abstract excerpt

PU.1 is a unique regulatory protein required for the generation of both the innate and the adaptive immune system. It functions exclusively in a cell-intrinsic manner to control the development of granulocytes, macrophages, and B and T lymphocytes. We demonstrate that mutation of the PU.1 gene causes a severe reduction in myeloid (granulocyte/macrophage) progenitors. PU.1 -/- myeloid progenitors can proliferate...

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Identifiers

PMID: 9687512
DOI: 10.1093/emboj/17.15.4456
PMCID: PMC1170777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors.PMID 9687512Read ↗

PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis.Semantic proximity Read ↗

Myeloid development is selectively disrupted in PU.1 null mice.Semantic proximity Read ↗

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.Semantic proximity Read ↗

PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors.Semantic proximity Read ↗

Surprising new roles for PU.1 in the adaptive immune response.Semantic proximity Read ↗

Analysis of concentration-dependent functions of PU.1 in hematopoiesis using mouse models.Semantic proximity Read ↗

Differential regulation of primitive myelopoiesis in the zebrafish by Spi-1/Pu.1 and C/ebp1.Semantic proximity Read ↗

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.Semantic proximity Read ↗

PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.Semantic proximity Read ↗

Reduction in PU.1 activity results in a block to B-cell development, abnormal myeloid proliferation, and neonatal lethality.Semantic proximity Read ↗

Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-BSemantic proximity Read ↗

The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction.Semantic proximity Read ↗

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