PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors.

doi:10.1093/emboj/17.15.4456

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Article

PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors.

The EMBO journal - 3 Aug 1998

DeKoter R P, Walsh J C, Singh H

Abstract excerpt

PU.1 is a unique regulatory protein required for the generation of both the innate and the adaptive immune system. It functions exclusively in a cell-intrinsic manner to control the development of granulocytes, macrophages, and B and T lymphocytes. We demonstrate that mutation of the PU.1 gene ca...

Topics

Animals
Cell Differentiation
Cell Division
Colony-Forming Units Assay
Cytokines
Female
Gene Expression Regulation
Genes, fms
Granulocyte Colony-Stimulating Factor
Granulocyte-Macrophage Colony-Stimulating Factor
Granulocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hematopoietic Stem Cells

Interleukin-3

Interleukin-6

Macrophage Colony-Stimulating Factor

Macrophages

Male

Mice

Source

Open in PubMed Open full text

Identifiers

PMID: 9687512
DOI: 10.1093/emboj/17.15.4456
PMCID: PMC1170777

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9687512-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors.PMID 9687512Read ↗

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