Reduction in PU.1 activity results in a block to B-cell development, abnormal myeloid proliferation, and neonatal lethality.

doi:10.1016/j.exphem.2007.04.005

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Article

Reduction in PU.1 activity results in a block to B-cell development, abnormal myeloid proliferation, and neonatal lethality.

Experimental hematology - 1 Jul 2007

Houston Isaac B, Kamath Meghana B, Schweitzer Brock L, Chlon Timothy M, DeKoter Rodney P

Abstract excerpt

OBJECTIVE: It has been demonstrated that high concentration of the transcription factor PU.1 (encoded by Sfpi1) promotes macrophage development, whereas low concentration induces B-cell development in vitro. This has led to the hypothesis that lower levels of PU.1 activity are required for B cell than for macrophage development in vivo. We utilized an allele of Sfpi1 (termed BN) with a mutation in the first...

Topics

Alleles
Animals
Animals, Newborn
B-Lymphocytes
Cell Proliferation
Cells, Cultured
Humans
Mice
Mice, Inbred C57BL
Myelopoiesis
Myeloproliferative Disorders
Proto-Oncogene Proteins
Trans-Activators

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Identifiers

PMID: 17588474
DOI: 10.1016/j.exphem.2007.04.005
PMCID: PMC1975786

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