Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Granulocyte inducer C/EBPα inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions

15 Jul 2002

Abstract excerpt

Several transcription factors have been implicated as playing a role in myelopoiesis. PU.1, an ets-family transcription factor, is required for the development of myeloid and lymphoid lineages, whereas the transcription factor CCAAT-enhancer binding protein family member C/EBPalpha is essential for granulocyte development. We present here the first evidence that C/EBPalpha blocks the function of PU.1. PU.1 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Histone Deacetylase Inhibitors Research
Share to Retinoids in leukemia and cellular processes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12091339
DOI: 10.1182/blood.v100.2.483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Granulocyte inducer C/EBPα inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisionsPMID 12091339Read ↗

c-Myc Is a Critical Target for C/EBPα in GranulopoiesisSemantic proximity Read ↗

Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.Semantic proximity Read ↗

Expression and regulation of C/EBPα in normal myelopoiesis and in malignant transformation.Semantic proximity Read ↗

Multiple ways of C/EBPalpha inhibition in myeloid leukaemia.Semantic proximity Read ↗

Induction of C/EBPα activity alters gene expression and differentiation of human CD34+ cellsSemantic proximity Read ↗

PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.Semantic proximity Read ↗

A dominant-negative mutant of C/EBPalpha, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse.Semantic proximity Read ↗

C/EBPα in normal and malignant myelopoiesis.Semantic proximity Read ↗

The Role of C/EBPε in the Terminal Stages of Granulocyte DifferentiationSemantic proximity Read ↗

Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML.Semantic proximity Read ↗

Novel Combinatorial Interactions of GATA-1, PU.1, and C/EBPε Isoforms Regulate Transcription of the Gene Encoding Eosinophil Granule Major Basic ProteinSemantic proximity Read ↗

PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.