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Article

Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.

Proceedings of the National Academy of Sciences of the United States of America - 30 Aug 2005

Walter Matthew J, Park John S, Ries Rhonda E, Lau Steven K M, McLellan Michael, Jaeger Sara, Wilson Richard K, Mardis Elaine R, Ley Timothy J

Abstract excerpt

PU.1 is a member of the ETS family of transcription factors that is known to be important for hematopoietic development. Recently, haploinsufficiency for PU.1 has been shown to cause a shift in myelomonocytic progenitor fate toward the myeloid lineage. We have previously shown that transgenic mice expressing PML-RARalpha (PR) and RARalpha-PML frequently develop acute promyelocytic leukemia (APL) in association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Promyelocytic, Acute

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Share to Oncogene Proteins, Fusion

Share to RNA, Neoplasm

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Source

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Identifiers

PMID: 16113082
DOI: 10.1073/pnas.0504247102
PMCID: PMC1188022

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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