Article
Differential regulation of primitive myelopoiesis in the zebrafish by Spi-1/Pu.1 and C/ebp1.
Zebrafish - 1 Jan 2007
Su Fengyun, Juarez Marianne A, Cooke Christopher L, Lapointe Lisa, Shavit Jordan A, Yamaoka Jennifer S, Lyons Susan E
Abstract excerpt
The zebrafish has become a powerful tool for analysis of vertebrate hematopoiesis. Zebrafish, unlike mammals, have a robust primitive myeloid pathway that generates both granulocytes and macrophages. It is not clear how this unique primitive myeloid pathway relates to mammalian definitive hematopoiesis. In this study, we show that the two myeloid subsets can be distinguished using RNA in situ hybridization. Using...
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