Article
PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors.
Genes & development - 1 Aug 1998
Nerlov C, Graf T
Abstract excerpt
Little is known about the transcription factors that mediate lineage commitment of multipotent hematopoietic precursors. One candidate is the Ets family transcription factor PU.1, which is expressed in myeloid and B cells and is required for the development of both these lineages. We show here th...
Topics
- Alleles
- Animals
- Cell Differentiation
- Chick Embryo
- DNA-Binding Proteins
- Erythroid-Specific DNA-Binding Factors
- GATA1 Transcription Factor
- Gene Expression Regulation, Developmental
- Hematopoiesis
- Hematopoietic Stem Cells
- Humans
- Proto-Oncogene Proteins
- Trans-Activators
- Transcription Factors
- Transformation, Genetic