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Article

PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors.

Genes & development - 1 Aug 1998

Nerlov C, Graf T

Abstract excerpt

Little is known about the transcription factors that mediate lineage commitment of multipotent hematopoietic precursors. One candidate is the Ets family transcription factor PU.1, which is expressed in myeloid and B cells and is required for the development of both these lineages. We show here that the factor specifically instructs transformed multipotent hematopoietic progenitors to differentiate along the...

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Identifiers

PMID: 9694804
DOI: 10.1101/gad.12.15.2403
PMCID: PMC317050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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