Article
Myeloid development is selectively disrupted in PU.1 null mice.
Blood - 15 May 1998
Anderson K L, Smith K A, Conners K, McKercher S R, Maki R A, Torbett B E
Abstract excerpt
The ets family transcription factor PU.1 is expressed in monocytes/macrophages, neutrophils, mast cells, B cells, and early erythroblasts, but not in T cells. We have recently shown that PU.1 gene disruption results in mice with no detectable monocytes/macrophages and B cells but T-cell development is retained. Although neutrophil development occurred in these mice, it was delayed and markedly reduced. We now...
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