Myeloid development is selectively disrupted in PU.1 null mice.

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Article

Myeloid development is selectively disrupted in PU.1 null mice.

Blood - 15 May 1998

Anderson K L, Smith K A, Conners K, McKercher S R, Maki R A, Torbett B E

Abstract excerpt

The ets family transcription factor PU.1 is expressed in monocytes/macrophages, neutrophils, mast cells, B cells, and early erythroblasts, but not in T cells. We have recently shown that PU.1 gene disruption results in mice with no detectable monocytes/macrophages and B cells but T-cell developme...

Topics

Animals
Cell Differentiation
Cell Division
Cells, Cultured
Colony-Forming Units Assay
Drug Resistance
Granulocyte Colony-Stimulating Factor
Granulocyte-Macrophage Colony-Stimulating Factor
Hematopoiesis
Hematopoietic Stem Cells
Immunologic Deficiency Syndromes
Leukopenia
Lymphocyte Subsets
Macrophage Colony-Stimulating Factor
Macrophages
Mice
Mice, Inbred C57BL
Mice, Knockout

Source

Open in PubMed

Identifiers

PMID: 9573007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9573007-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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