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Article

Role of the endoplasmic reticulum unfolded protein response in glomerular epithelial cell injury.

The Journal of biological chemistry - 1 Jul 2005

Cybulsky Andrey V, Takano Tomoko, Papillon Joan, Bijian Krikor

Abstract excerpt

C5b-9-induced glomerular epithelial cell (GEC) injury in vivo (in passive Heymann nephritis) and in culture is associated with damage to the endoplasmic reticulum (ER) and increased expression of ER stress proteins. Induction of ER stress proteins is enhanced via cytosolic phospholipase A(2) (cPLA(2)) and limits complement-dependent cytotoxicity. The present study addresses another aspect of the ER unfolded...

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PMID: 15863508
DOI: 10.1074/jbc.M500729200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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