Article
Cyclosporine-induced endoplasmic reticulum stress triggers tubular phenotypic changes and death.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Nov 2008
Pallet N, Bouvier N, Bendjallabah A, Rabant M, Flinois J P, Hertig A, Legendre C, Beaune P, Thervet E, Anglicheau D
Abstract excerpt
The molecular mechanisms by which cyclosporine induces chronic nephrotoxicity remain poorly understood. A previous transcriptomic study suggested that cyclosporine might induce endoplasmic reticulum (ER) stress in human tubular cells. The aim of the present study was to characterize the features of tubular ER stress induced by cyclosporine and to investigate its effects on cell differentiation and viability....
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