Article
APOL1 risk variants cause podocytes injury through enhancing endoplasmic reticulum stress.
Bioscience reports - 31 Aug 2018
Wen Hongxiu, Kumar Vinod, Lan Xiqian, Shoshtari Seyedeh Shadafarin Marashi, Eng Judith M, Zhou Xiaogang, Wang Fang, Wang Haichao, Skorecki Karl, Xing Guolan, Wu Guisheng, Luo Huairong, Malhotra Ashwani, Singhal Pravin C
Abstract excerpt
Two coding sequence variants (G1 and G2) of Apolipoprotein L1 (APOL1) gene have been implicated as a higher risk factor for chronic kidney diseases (CKD) in African Americans when compared with European Americans. Previous studies have suggested that the APOL1 G1 and G2 variant proteins are more toxic to kidney cells than the wild-type APOL1 G0, but the underlying mechanisms are poorly understood. To determine...
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