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Article

A maladaptive role for EP4 receptors in podocytes.

Journal of the American Society of Nephrology : JASN - 1 Oct 2010

Stitt-Cavanagh Erin M, Faour Wissam H, Takami Kaede, Carter Anthony, Vanderhyden Barbara, Guan Youfei, Schneider Andre, Breyer Matthew D, Kennedy Christopher R J

Abstract excerpt

Inhibition of p38 mitogen-activated protein kinase and cyclooxygenase-2 reduces albuminuria in models of chronic kidney disease marked by podocyte injury. Previously, we identified a feedback loop in podocytes whereby an in vitro surrogate for glomerular capillary pressure (i.e., mechanical stretch) along with prostaglandin E(2) stimulation of its EP4 receptor induced cyclooxygenase-2 in a p38-dependent manner....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20671216
DOI: 10.1681/ASN.2009121234
PMCID: PMC3013547

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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