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Article

Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: a role for endothelial phenotypic changes and death.

American journal of physiology. Renal physiology - 1 Jan 2009

Bouvier Nicolas, Flinois Jean Pierre, Gilleron Jerome, Sauvage François-Ludovic, Legendre Christophe, Beaune Philippe, Thervet Eric, Anglicheau Dany, Pallet Nicolas

Abstract excerpt

Calcineurin inhibitors cyclosporine and tacrolimus are effective immunosuppressants, but both substances have the same intrinsic nephrotoxic potential that adversely affects allograft survival in renal transplant patients and causes end-stage renal disease in other solid organ or bone marrow transplant recipients. Endothelial cells are the first biological interface between drugs and the kidney, and calcineurin...

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Identifiers

PMID: 18987109
DOI: 10.1152/ajprenal.90567.2008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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