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Article

Increased susceptibility of aging kidney to ischemic injury: identification of candidate genes changed during aging, but corrected by caloric restriction.

American journal of physiology. Renal physiology - 1 Oct 2007

Chen G, Bridenbaugh E A, Akintola A D, Catania J M, Vaidya V S, Bonventre J V, Dearman A C, Sampson H W, Zawieja D C, Burghardt R C, Parrish A R

Abstract excerpt

Aging is associated with an increased incidence and severity of acute renal failure. However, the molecular mechanism underlying the increased susceptibility to injury remains undefined. These experiments were designed to investigate the influence of age on the response of the kidney to ischemic injury and to identify candidate genes that may mediate this response. Renal slices prepared from young (5 mo), aged ad...

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Identifiers

PMID: 17670906
DOI: 10.1152/ajprenal.00138.2007
PMCID: PMC2758575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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