Article
Rapid renal alpha-1 antitrypsin gene induction in experimental and clinical acute kidney injury.
PloS one - 1 Jan 2014
Zager Richard A, Johnson Ali C M, Frostad Kirsten B
Abstract excerpt
Alpha-1-antitrypsin (AAT) is a hepatic stress protein with protease inhibitor activity. Recent evidence indicates that ischemic or toxic injury can evoke selective changes within kidney that resemble a hepatic phenotype. Hence, we tested the following: i) Does acute kidney injury (AKI) up-regulate the normally renal silent AAT gene? ii) Does rapid urinary AAT excretion result? And iii) Can AAT's...
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