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Article

Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway.

Biochimica et biophysica acta - 1 Sept 2016

Cybulsky Andrey V, Guillemette Julie, Papillon Joan

Abstract excerpt

Expression and activation of SLK increases during renal ischemia-reperfusion injury. When highly expressed, SLK signals via c-Jun N-terminal kinase and p38 to induce apoptosis, and it exacerbates apoptosis induced by ischemia-reperfusion injury. Overexpression of SLK in glomerular epithelial cells (GECs)/podocytes in vivo induces injury and proteinuria. In response to various stresses, cells enhance expression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27216364
DOI: 10.1016/j.bbamcr.2016.05.015

Genes

SLK
HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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