Article
Unfolded protein response causes a phenotypic shift of inflamed glomerular cells toward redifferentiation through dual blockade of Akt and Smad signaling pathways.
The American journal of pathology - 1 Dec 2012
Johno Hisashi, Nakajima Shotaro, Kato Hironori, Yao Jian, Paton Adrienne W, Paton James C, Katoh Ryohei, Shimizu Fujio, Kitamura Masanori
Abstract excerpt
During recovery from acute glomerulonephritis, cell proliferation, matrix expansion, and expression of the dedifferentiation marker α-smooth muscle actin (α-SMA) subside spontaneously. However, the molecular mechanisms underlying this recovery process remain elusive. In mesangioproliferative glomerulonephritis, the unfolded protein response (UPR) is induced in activated, dedifferentiated mesangial cells. We...
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