Article
Perk is essential for translational regulation and cell survival during the unfolded protein response.
Molecular cell - 1 May 2000
Harding H P, Zhang Y, Bertolotti A, Zeng H, Ron D
Abstract excerpt
Malfolded proteins in the endoplasmic reticulum (ER) inhibit translation initiation. This response is believed to be mediated by increased phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha) and is hypothesized to reduce the work load imposed on the folding machinery during stress. Here we report that mutating the gene encoding the ER stress-activated eIF2alpha kinase PERK abolishes the...
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