Article
Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alpha.
Human molecular genetics - 15 Oct 2008
Liang Genqing, Yang JungWoo, Wang Zuocheng, Li Qiang, Tang Yan, Chen Xing-Zhen
Abstract excerpt
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of renal, hepatic and pancreatic cysts and by non-cystic manifestations such as abnormal vasculature and embryo left-right asymmetry development. Polycystin-2 (PC2), in which mutations account for 10-15% of ADPKD, was previously shown to down-regulate cell proliferation, but the underlying mechanism was not elucidated. Here, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.