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Article

The HBx protein from hepatitis B virus coordinates a redox-active Fe-S cluster.

The Journal of biological chemistry - 1 Apr 2022

Ueda Chie, Langton Michelle, Chen Jiahua, Pandelia Maria-Eirini

Abstract excerpt

The viral protein HBx is the key regulatory factor of the hepatitis B virus (HBV) and the main etiology for HBV-associated liver diseases, such as cirrhosis and hepatocellular carcinoma. Historically, HBx has defied biochemical and structural characterization, deterring efforts to understand its molecular mechanisms. Here we show that soluble HBx fused to solubility tags copurifies with either a [2Fe-2S] or a...

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Identifiers

PMID: 35148994
DOI: 10.1016/j.jbc.2022.101698
PMCID: PMC9010755

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