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Article

Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus covalently closed circular DNA.

The Journal of biological chemistry - 1 Jan 2000

Meier-Stephenson Vanessa, Badmalia Maulik D, Mrozowich Tyler, Lau Keith C K, Schultz Sarah K, Gemmill Darren L, Osiowy Carla, van Marle Guido, Coffin Carla S, Patel Trushar R

Abstract excerpt

Approximately 250 million people worldwide are chronically infected with the hepatitis B virus (HBV) and are at increased risk of developing cirrhosis and hepatocellular carcinoma. The HBV genome persists as covalently closed circular DNA (cccDNA), which serves as the template for all HBV mRNA transcripts. Current nucleos(t)ide analogs used to treat HBV do not directly target the HBV cccDNA genome and thus cannot...

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Share to DNA, Circular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

Source

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Identifiers

PMID: 33774051
DOI: 10.1016/j.jbc.2021.100589
PMCID: PMC8094906

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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