Article

Promiscuous Metal Site in Hepatitis B Virus X Protein Binds an Fe-S Cluster

2026-01-21

Abstract excerpt

The Hepatitis B virus (HBV) regulatory protein HBx is essential for viral replication and pathogenesis, yet its cofactor specificity and ligand environment remain poorly defined. Although HBx binds either an Fe-S cluster or Zn, its intrinsic disorder and mutational tolerance have hindered its precise characterization. Here, we integrate chemoproteomics with HYSCORE spectroscopy to identify the metal-coordinating l...

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Literature Corpus work: 7f77a72f-fe83-58cf-b6d2-9909118b0b7a
DOI: 10.64898/2026.01.20.700672

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