Article
Hepatitis B virus, HBx mutants and their role in hepatocellular carcinoma.
World journal of gastroenterology - 14 Aug 2014
Ali Ashraf, Abdel-Hafiz Hany, Suhail Mohd, Al-Mars Amany, Zakaria Mohammad Khalid, Fatima Kaneez, Ahmad Sultan, Azhar Esam, Chaudhary Adeel, Qadri Ishtiaq
Abstract excerpt
Hepatocellular carcinoma (HCC) is one of the leading causes of death induced by cancer in the modern world and majority of the cases are related to chronic hepatitis B virus (HBV) infection. HBV-encoded X protein (HBx) is known to play a pivotal role in the pathogenesis of viral induced HCC. HBx...
Topics
- Animals
- Carcinoma, Hepatocellular
- Cell Transformation, Viral
- Gene Expression Regulation, Neoplastic
- Gene Expression Regulation, Viral
- Genotype
- Hepatitis B
- Hepatitis B virus
- Host-Pathogen Interactions
- Humans
- Liver Neoplasms
- MicroRNAs
- Mutation
- Trans-Activators