Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample.

Human genetics - 1 Jun 2005

Weiss Lauren A, Abney Mark, Parry Rodney, Scanu Angelo M, Cook Edwin H, Ober Carole

Abstract excerpt

A recent genome-scan identified the Leu33Pro polymorphism in the beta3 integrin (ITGB3) gene as a quantitative trait locus for whole blood serotonin level in a large Hutterite pedigree. Because both the Leu33Pro polymorphism and the serotonin system have been implicated in cardiovascular disease (CVD) risk and treatment response, we studied additional variation in ITGB3 and its relationship to intermediate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Pressure
Share to Cardiovascular Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Founder Effect

Share to Integrin beta3

Share to Lipoproteins

Share to Protein Precursors

Share to Serotonin

Share to Sex Factors

Source

Identifiers

PMID: 15834589
DOI: 10.1007/s00439-004-1250-3

Genes

ITGB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample.PMID 15834589Read ↗

Variation in ITGB3 is associated with whole-blood serotonin level and autism susceptibility.Semantic proximity Read ↗

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.Semantic proximity Read ↗

ITGB3 shows genetic and expression interaction with SLC6A4.Semantic proximity Read ↗

Association study between variants in the fibrinogen gene cluster, fibrinogen levels and hypertension: results from the MONICA/KORA study.Semantic proximity Read ↗

Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study.Semantic proximity Read ↗

Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels.Semantic proximity Read ↗

Genetic implication of a novel thiamine transporter in human hypertension.Semantic proximity Read ↗

Family-based association study of ITGB3 in autism spectrum disorder and its endophenotypes.Semantic proximity Read ↗

G-protein beta3 subunit (GNB3) gene polymorphisms and cardiovascular disease: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study.Semantic proximity Read ↗

The Gain-of-Function Integrin β3 Pro33 Variant Alters the Serotonin System in the Mouse Brain.Semantic proximity Read ↗

Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.Semantic proximity Read ↗

Mean platelet volume and integrin alleles correlate with levels of integrins α(IIb)β(3) and α(2)β(1) in acute coronary syndrome patients and normal subjects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.