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Article

ITGB3 shows genetic and expression interaction with SLC6A4.

Human genetics - 1 Aug 2006

Weiss Lauren A, Ober Carole, Cook Edwin H

Abstract excerpt

Autism affects more males than females and is associated with disturbances of the serotonin system. The integrin beta3 (ITGB3) and serotonin transporter (SLC6A4) genes were both recently identified as male quantitative trait loci (QTLs) for serotonin levels and alleles of each have been associated with autism. Here, we use publicly available genomic resources to determine whether regulation of expression level...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16721604
DOI: 10.1007/s00439-006-0196-z

Genes

ITGB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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ITGB3 shows genetic and expression interaction with SLC6A4.PMID 16721604Read ↗

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Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population.Semantic proximity Read ↗

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Integrative analyses indicate an association between ITIH3 polymorphisms with autism spectrum disorder.Semantic proximity Read ↗

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Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample.Semantic proximity Read ↗

Lack of association between markers in the ITGA3, ITGAV, ITGA6 and ITGB3 and autism in an Irish sample.Semantic proximity Read ↗

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Examination of association of genes in the serotonin system to autism.Semantic proximity Read ↗

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