Article
Family-based association study of ITGB3 in autism spectrum disorder and its endophenotypes.
European journal of human genetics : EJHG - 1 Mar 2011
Napolioni Valerio, Lombardi Federica, Sacco Roberto, Curatolo Paolo, Manzi Barbara, Alessandrelli Riccardo, Militerni Roberto, Bravaccio Carmela, Lenti Carlo, Saccani Monica, Schneider Cindy, Melmed Raun, Pascucci Tiziana, Puglisi-Allegra Stefano, Reichelt Karl-Ludvig, Rousseau Francis, Lewin Patricia, Persico Antonio M
Abstract excerpt
The integrin-β 3 gene (ITGB3), located on human chromosome 17q21.3, was previously identified as a quantitative trait locus (QTL) for 5-HT blood levels and has been implicated as a candidate gene for autism spectrum disorder (ASD). We performed a family-based association study in 281 simplex and 12 multiplex Caucasian families. ITGB3 haplotypes are significantly associated with autism (HBAT, global P=0.038)....
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