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Article

Variation in ITGB3 is associated with whole-blood serotonin level and autism susceptibility.

European journal of human genetics : EJHG - 1 Aug 2006

Weiss Lauren A, Kosova Gülüm, Delahanty Ryan J, Jiang Lan, Cook Edwin H, Ober Carole, Sutcliffe James S

Abstract excerpt

Autism is a pervasive developmental disorder affecting more males than females. Heritability estimates for autism can rise above 90%, and genes influencing the serotonin system are strong candidates for autism susceptibility genes, as drugs selectively acting on the serotonin system are some of t...

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Source

Identifiers

PMID: 16724005
DOI: 10.1038/sj.ejhg.5201644

Genes

ITGB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16724005-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Variation in ITGB3 is associated with whole-blood serotonin level and autism susceptibility.PMID 16724005Read ↗

ITGB3 shows genetic and expression interaction with SLC6A4.Semantic proximity Read ↗

Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population.Semantic proximity Read ↗

Association and gene-gene interaction of SLC6A4 and ITGB3 in autism.Semantic proximity Read ↗

Family-based association study of ITGB3 in autism spectrum disorder and its endophenotypes.Semantic proximity Read ↗

Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels.Semantic proximity Read ↗

Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism.Semantic proximity Read ↗

The Gain-of-Function Integrin β3 Pro33 Variant Alters the Serotonin System in the Mouse Brain.Semantic proximity Read ↗

Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample.Semantic proximity Read ↗

The involvement of serotonin polymorphisms in autistic spectrum symptomatology.Semantic proximity Read ↗

Examination of association of genes in the serotonin system to autism.Semantic proximity Read ↗

Genetic variants of MAOB affect serotonin level and specific behavioral attributes to increase autism spectrum disorder (ASD) susceptibility in males.Semantic proximity Read ↗

Clinical, developmental and serotonemia phenotyping of a sample of 70 Italian patients with Phelan-McDermid Syndrome.Semantic proximity Read ↗

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